Abstract

Liquid chromatography-mass spectrometry (LC-MS)-based quantitative proteomics has become increasingly applied to a wide range of biological applications due to growing capabilities for broad proteome coverage and good accuracy in quantification. Herein, we review the current LC-MS-based quantification methods with respect to their advantages and limitations, and highlight their potential applications.

The article is published online in the Journal of Biological Chemistry and is free to access.