Mapping Structures and Functions of a Transient Enzyme State

News   Jun 19, 2017 | Original story from Umeå University

 
Mapping Structures and Functions of a Transient Enzyme State

High resolution x-ray structure of the enzyme adenylate kinase trapped in a transient structural state by a covalent disulfide bond. Credit: Magnus Wolf-Watz

 
 
 

RELATED ARTICLES

Targeting a Leaky Protein that Causes Paralysis

News

A rare genetic disorder in which people are overcome suddenly with profound muscle weakness is caused by a hole in a membrane protein that allows sodium ions to leak across cell membranes. Compounds containing a chemical group called guanidinium can block the pore created by the mutation and stop the sodium leak without altering the voltage sensor’s ability to function.

READ MORE

Using Diamonds to Create Drug Discovery Tools

News

Team led by Berkeley Lab and UC Berkeley researchers exploits tiny defects in diamonds to pave the way for enhanced biological imaging and drug studies

READ MORE

Cellular Valve Structure Opens Up Potential Novel Therapies

News

Biochemists have determined the detailed structure of a volume-regulated chloride channel. This cellular valve is activated in response to swelling to prevent the cell from bursting. The protein also plays an important role in the uptake of chemotherapeutics and the release of neurotransmitters after a stroke. The controlled regulation of its activity thus opens up a promising strategy for novel therapies.

READ MORE

 

Comments | 0 ADD COMMENT

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE