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Neutrons Observe Vitamin B6-dependent Enzyme Activity Useful for Drug Development

News   Oct 19, 2017 | Original Story from Oak Ridge National Laboratory

 
Neutrons Observe Vitamin B6-dependent Enzyme Activity Useful for Drug Development

An ORNL-led team used neutrons to observe the AAT enzyme, a vitamin B6-dependent protein, and found that the chemical reaction occurred only in one active site. Nuclear scattering length density maps (colored mesh) highlight the positions of critical hydrogen atoms, including a low-barrier hydrogen bond (magenta mesh) not thought to exist in AAT, which may be crucial for catalysis. Credit: Jill Hemman and Andrey Kovalevsky /Oak Ridge National Laboratory, US Dept. of Energy.

 
 
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