Bisphenol A (BPA) is a chemical that is employed in the manufacture of certain materials, including polycarbonate and epoxy resins. Recently, the use of BPA was restricted, which may cause the industry to switch to alternative substances. The chemical structure of many alternatives is close to BPA. To date, little is known about the occurrence of these BPA analogues in food. The JRC-Institute for Reference Materials and Measurements (IRMM) developed suitable analytical methods for the determination of BPA and 12 BPA analogues in complex food. In the future, the need to generate reliable occurrence data may arise. The analytical methods are characterised by high selectivity and sensitivity, allowing the determination of these substances at the sub-microgram per kilogram level.