Novel Organotin(IV)-Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Activity and DNA Interaction Studies
News Jan 25, 2011
Organotin(IV) complexes have been the subject of interest for some time because of their biomedical and commercial applications. It has been observed that several organotin complexes are effective antifouling, antimicrobial and antiviral agents. The work reported within this article demonstrates details studies of four novel organotin(IV) complexes.
Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino- N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes 1 and 3 with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex 1 can act as effective DNA cleaving agent when compared to complex 3 resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.
The article is published online within the journal, Bioinorganic Chemistry and Applications and is free to access.