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Painting Molecular Pictures at Super-resolution

News   Sep 17, 2019 | Original story from the Wyss Institute.

 
Painting Molecular Pictures at Super-resolution

The team demonstrated the capabilities of Action-PAINT on synthetic DNA nanostructures exposing identical nearby docking sites for imager strands. In a first step the docking sites were visualized by super-resolution microscopy (left), then, with the help of a special software package, manually selected individual docking sites were labeled by crosslinking the imager strands to them with UV-radiation (middle), and finally, successful labeling events were verified by an additional round of super-resolution microscopy (right). Credit: Wyss Institute at Harvard University.

 
 
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