Study Shows Detection of Hydrocodone and Morphine as Metabolites of Codeine
Millennium Health announced the publication of a new study that identifies hydrocodone and morphine as metabolites in oral fluid using Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS) in patients prescribed codeine. The study was published in the February 2017 issue of Therapeutic Drug Monitoring.
“Understanding that hydrocodone and morphine may be found as metabolites for patients prescribed codeine helps improve interpretation of oral fluid testing used to monitor patients prescribed opioids,” said Maria Guevara, Pharm.D., director of clinical affairs, education and training, Millennium Health. “In a clinical context, it could mean that a clinician does not falsely accuse a patient of having taken a concomitant medication.”
In the study, oral fluid samples were collected and submitted to Millennium for routine drug testing using LC-MS/MS. Consistent with previously published literature, codeine was the primary analyte detected in oral fluid after the use of codeine. In codeine-positive samples, hydrocodone, morphine, and norhydrocodone were detected. In contrast to urine, where hydrocodone is typically detected as a minor metabolite of codeine, hydrocodone was the most commonly detected metabolite in oral fluid samples testing positive for codeine with reported prescriptions for codeine.
The results of the study suggest that care should be taken when interpreting hydrocodone positives in oral fluid test results, and that the use of codeine should be considered as one possible explanation for hydrocodone and morphine positives.
West, R. E., Guevara, M. G., Mikel, C., & Gamez, R. (2017). Detection of Hydrocodone and morphine as metabolites in oral fluid by LC-MS/MS in patients prescribed Codeine. Therapeutic Drug Monitoring, 39(1), 88–90. doi:10.1097/ftd.0000000000000365
This article has been republished from materials provided by Millennium Health. Note: material may have been edited for length and content. For further information, please contact the cited source.
Easily Automate PK Assays for Human IgG Drugs in Preclinical SpeciesNews
At AAPS NBC event, Lumigen produced a poster summarizing the use of their pipetting robot, Andrew which can measure IgG drug concentration in a pre-clinical setting.READ MORE
Could This Be a "Silver Bullet" for Preventing and Treating Colon Cancer?News
A team of scientists targeted the gene CtBP with a drug known as HIPP (2-hydroxy-imino phenylpyruvic acid) and were able to reduce the development of pre-cancerous polyps by half.READ MORE
Ingestible Drug-Delivery Materials May Improve Patient Treatment ComplianceNews
Hydrogel-based capsules could expand and reside in the GI tract for days, slowly releasing medication.READ MORE
Comments | 0 ADD COMMENT
Theme: Gathering the Newborn Advances in Cardiology
Mar 19 - Mar 20, 2018
6th Edition of International Conference on Pharmacognosy and Medicinal Plants
Apr 16 - Apr 17, 2018
10th Edition of International Conference on Structural Biology 2018
Mar 15 - Mar 17, 2018