Targeting Cannabinoid CB2 Receptors in the CNS
News Oct 19, 2016
Endocannabinoids activate two types of specific G-protein coupled receptors (GPCRs), namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 receptors, and serious side effects of the selective antagonists of this receptor, drugs acting on CB2 receptors appear as promising drugs to combat CNS diseases (Parkinson’s disease, Huntington’s chorea, cerebellarataxia, amyotrohiclateralsclerosis). Differential localization of CB2 receptors in neural cell types and up regulation in neuroinflammation are keys to understand the therapeutic potential in inter alia diseases that imply progressive neurodegeneration. Medicinal chemistry approaches are now engaged to develop imaging tools to map receptors in the living human brain, to develop more efficacious agonists, and to investigate the possibility to develop allosteric modulators.
The full article, Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders, is published in Frontiers in Neuroscience and can be accessed free of charge.
Forensic Analysis Sheds Light on Ligament InjuriesNews
A team have used a forensic approach to reconstruct injuries by examining bone bruises on the knees of 15 men and 15 women with torn anterior cruciate ligaments (ACL). This showed while women are two to four times more likely than men to tear the ACL in their knee, the cause of this injury is no different between the sexes.READ MORE
Flavins Keep a Handy Helper in Their PocketNews
A team has now shown in detail how oxygen interacts with the flavin in an enzyme - revealing for the first time precisely how it works. Flavins play a key role in metabolic processes, in the immune system and in neural development in humans - and are equally important to bacteria, fungi and plants.READ MORE