Thermo Fisher Scientific and PREMIER Biosoft to Co-market SimGlycan Software
News Jan 06, 2012
Thermo Fisher Scientific Inc., and PREMIER Biosoft announces an agreement to co-market PREMIER Biosoft’s SimGlycan® software. The agreement aims to advance glycobiology by dramatically speeding the characterization of complex glycans through automated interpretation of the rich data produced by Thermo Scientific mass spectrometer systems.
Glycans—oligosaccharide or polysaccharide molecules found attached to proteins and lipids in virtually all multicellular organisms—serve essential roles in biological processes as diverse as protein folding, immune function, and energy storage. Because glycans have the potential to serve as markers for disease, and because changes to glycans in a biologically based drug can affect the drug’s function, bioinformatics tools that simplify and expedite structural elucidation of glycans are of intense interest to the scientific community and the pharmaceutical industry.
“The agreement enables Thermo Fisher Scientific to offer an integrated solution that markedly speeds glycan characterization,” said Andreas Huhmer, proteomics marketing director for life sciences mass spectrometry at Thermo Fisher Scientific. “SimGlycan software is the only glycan characterization software available today that can comprehensively analyze the high-quality MSn glycan data generated by Thermo Scientific mass spectrometers. Higher order MSn fragmentation data are essential to resolving glycan heterogeneity and isomeric forms.”
“The complex branching and isomeric nature of glycans have created significant analytical challenges for glycobiologists,” said Kay Brown, President, PREMIER Biosoft. “By co-marketing SimGlycan software with the market leader in multistage mass spectrometer systems, PREMIER Biosoft leverages a broader sales and marketing channel to address these challenges.”
Due to the sensitivity of mass spectrometers and their ability to analyze complex glycan mixtures, mass spectrometry has emerged as a powerful tool for glycan structural elucidation. However, MS-based approaches generate large volumes of data that, until the introduction of SimGlycan software, required hours or days of tedious manual interpretation. SimGlycan software automatically matches experimentally acquired mass spectra against a comprehensive database and generates a list of candidate glycan structures scored to reflect match quality. Additional, relevant biological information about the proposed glycan structure such as glycan class and biological pathway are made immediately available via interactive links.
Unlike other software, SimGlycan can process the multi-stage/sequential mass spectrometry (MSn) data produced by Thermo Scientific mass spectrometers. This unique capability aids in discriminating between glycans that have similar fragment ions at the MS/MS level, and resolves their carbohydrate distribution and branching patterns. Up to six or seven levels of fragmentation are typically needed to differentiate between glycan structural isomers.
SimGlycan software is designed for use with Thermo Scientific Orbitrap and ion trap mass spectrometers, including the Thermo Scientific LTQ, LTQ Velos and Velos Pro linear ion trap systems and the LTQ Orbitrap XL, Orbitrap Velos, Orbitrap Velos Pro, Orbitrap Elite and MALDI Orbitrap hybrid systems.
Synthetic DNA Shuffling Enzyme Outpaces Natural CounterpartNews
A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. Researchers say their lipid-scrambling DNA enzyme is the first in its class to outperform naturally occurring enzymes – and does so by three orders of magnitudeREAD MORE
Eating Activates Calorie-Burning FatNews
The importance of the human brown adipose tissue (BAT) has become clearer during the past ten years. Coldness is one of the most effective activators of the BAT metabolic function but, in rodents, eating has also been shown to activate BAT. The debate on whether eating has the same effect on humans has lasted for decades. Now, the researchers at Turku PET Centre have proven that having a meal increases oxygen consumption in human BAT to the same extent as coldness.READ MORE
Penn Medicine Biochemist Receives Major Award for Research on Epigenetic Protein Modifications via Mass SpecNews
Benjamin A.Garcia, PhD, an expert in quantitative proteomics and Presidential Professor of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania, has been awarded the Biemann Medal by the American Society for Mass Spectrometry (ASMS). The early-career award recognizes significant achievement in basic or applied mass spectrometry.