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University of Leeds Expands Structural Biology with Purchase of 2 Cryo-TEMs

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FEI has announced the receipt of a significant order for two Titan Krios™ cryo transmission electron microscopes (cryo-TEMs) from the University of Leeds, based in the United Kingdom. The Titan Krios is the most powerful high-resolution electron microscope for two-dimensional (2D) and three-dimensional (3D) characterization of protein structures and protein complexes.

“The Titan Krios is an amazingly powerful tool for structural biology that is in huge demand by researchers right now,” said Dr. Neil Ranson, Associate Professor, School of Molecular and Cellular Biology, University of Leeds. “Currently, there are only two Titan Krios systems in the U.K., with a couple more on the way. There is an insatiable demand for time on microscopes with these capabilities, and access is very difficult to come by. We are very excited to be able to purchase two Titan Krios systems with direct electron detecting cameras; they will help to establish Leeds as one of the leading centers for cryo-TEM research in the U.K. and in the world.”

“Cryo-TEM is undergoing unprecedented growth because improvements in microscopes and detectors now enable close-to-atomic resolution structures for many biological systems,” said Professor Sheena Radford, Astbury Professor of Biophysics and Director of the Astbury Centre. “However the full potential of cryo-EM will come as a result of the synergy with other technologies, such as X-ray diffraction (XRD) and nuclear magnetic resonance spectrometry (NMR). The University of Leeds is also acquiring a new, state-of-the-art 950MHz NMR instrument dedicated to biological research in the Astbury Centre.”

Peter Fruhstorfer, FEI’s Vice President and General Manager of the Life Sciences business, stated, “We are delighted that the University of Leeds has selected the Titan Krios TEM, and we anticipate great results from the University’s combined use of cryo-TEM, with XRD and NMR technology.” He adds, “The ability to purchase two systems is significant and will give the University the flexibility to conduct not only its own structural biology research, but also to build collaborations with researchers at other universities and institutions.”

The two Krios systems were purchased as part of a £17M investment from the University’s strategic reserves, an indication of the highest priority given to the acquisition by the University’s leaders. The initiative is also supported by a £1M award from the Wellcome Trust to support biomedical discovery.

The installation of the systems will begin in March 2016. For more information about the structural biology solutions from FEI, visit http://www.fei.com/life-sciences/structural-biology.