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Waters Corporation and Advion BioSciences Announce Collaboration

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Waters Corporation and Advion Biosciences, Inc. of Ithaca, NY have announced the completion of the evaluation phase of a joint effort to integrate the Advion TriVersa NanoMate chip-based infusion technology with the Waters® Synapt High Definition MS™ System. The announcement came during the 23rd LC-MS Montreux Symposium, November 8 - 10.

The co-marketing collaboration is designed to maximize the amount of information researchers can extract from their complex samples by combining the reproducibility of Advion’s nanoelectrospray chip-based sample introduction technology with the additional dimension of ion mobility-based separation provided by the Waters Synapt™ HDMS System.

"The Synapt HDMS System has attracted significant interest from leading biological researchers wishing to exploit its unique combination of high-sensitivity ion mobility and tandem mass spectrometry to provide information that is beyond the capabilities of conventional mass spectrometers, namely its ability to probe the size and shape of ions," said Dr. Alan Millar, HDMS Program Manager at Waters Corporation.

Said Dr. Jack Henion, co-founder and Chief Scientific Officer and Chairman of Advion BioSciences, "A prerequisite for many investigations of this type is the ability to maintain the native conformation of protein or peptide ions into the gas phase."

"This is typically achieved through the use of neutral pH solvents and low infusion flow rates; an area where the TriVersa NanoMate system can provide demonstrable benefits in terms of ease-of-use and reproducibility."

Dr. Henion will discuss some of the initial data acquired on a TriVersa-enabled Synapt HDMS System during his presentation "Recent Developments in Chip-Based Nanoelectrospray Applied to Qualitative and Quantitative Analyses" on Thursday morning, November 9 in Montreux, Switzerland.

The Waters Synapt High Definition MS system combines ion mobility with high-performance tandem mass spectrometry to enable the analysis of samples differentiated by size, shape and charge, as well as mass.

Operational control and data acquisition and processing are performed through Waters MassLynx™ software.

Primary applications include the analysis of monoclonal antibodies, multi-protein and protein-ligand complexes, top down proteomics and metabolite identification.