Xceleron and Sanofi-Aventis Sign Deal to Address Challenges in Exploratory Clinical Development
News Jun 12, 2007
Xceleron has announced that, following signature of a Master Services Agreement with Sanofi-Aventis Deutschland GmbH, a number of studies are underway to assess the human metabolism of novel compounds in early clinical development. This work utilises Xceleron’s ultra-sensitive Accelerator Mass Spectrometry (AMS) technology platform.
This latest deal adds to Xceleron’s growing client list of major organisations – including 15 of the world’s top 20 pharma companies.
Xceleron’s foundation in 1997 was supported by GSK, Novartis, Pfizer and Janssen (now Johnson & Johnson). Notably after many years of working with Xceleron to explore the potential of AMS, GSK now have 2 AMS machines of their own - focused specifically on similar kinds of metabolite profiling studies to those now being undertaken by Sanofi-Aventis.
Synthetic DNA Shuffling Enzyme Outpaces Natural CounterpartNews
A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. Researchers say their lipid-scrambling DNA enzyme is the first in its class to outperform naturally occurring enzymes – and does so by three orders of magnitudeREAD MORE
Simple Sugar Prevents Neurodegeneration in Lysosomal Storage DiseaseNews
New therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB (MPS IIIB)READ MORE
Eating Activates Calorie-Burning FatNews
The importance of the human brown adipose tissue (BAT) has become clearer during the past ten years. Coldness is one of the most effective activators of the BAT metabolic function but, in rodents, eating has also been shown to activate BAT. The debate on whether eating has the same effect on humans has lasted for decades. Now, the researchers at Turku PET Centre have proven that having a meal increases oxygen consumption in human BAT to the same extent as coldness.READ MORE