Latest Posters
Poster
Automated Fluorescence Detection and Imaging of RNA Species in Live Cells
This poster describes the detection and quantification of RNA species in Live cells through automated imaging.
Poster
The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.
Poster
Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.
Poster
Characterization of Proteins and Protein Self Association (Oligomerization) with SEC-MALS
In this poster, a series of proteins and their oligomers were characterized using SEC-MALS with UV and RI detection. The monomer molecular weights are measured and compared with those from column calibration. The molecular weights of their oligomers are also compared with column calibration and the differences explored.
Poster
Validation of a 3-Dimensional Human Liver Microtissue Model for Long-term Hepatotoxicity Studies
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drug commonly used as analgesics and antipyretics, as well as for management of rheumatological disorders. They are one of the most highly prescribed drug families around the world, and consequently, along with antimicrobial agents, are the most frequent causes of druginduced liver injury (DILI) (Bjornsson et al., 2010).
Poster
Identifying Molecular Signatures of Tumors Using Novel Fluorescence Resonance Energy Transfer Networks
We developed FRET sensors that can detect 125 fluorophores simultaneously. From experimental analyses of over 1200 time-resolved fluorescence signatures on 300 prototypical sensors, we show that the optical responses are highly repeatable and minor variations between FRET networks can be discriminated resulting in a total of 10^375 unique responses in theory.
Poster
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
Poster
Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.
Poster
Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases
Targeted nanoparticle-based drug delivery to the lungs is an emerging area of interest for both scientists and medical workers because it allows better drug retention in the lungs and can provide prolonged drug release. In our study we investigated the potential of using liposomes and polymeric nanoparticles surface modified with a specific antibody as drug carriers for targeted drug delivery to the lungs.
Poster
Print Nanoparticle Vaccine Carrying Bacterial Polysaccharide And Protein Antigens Induces Enhanced B- And T-Cell (Il-17) Immunity
Antigenic multivalent PRINT nanoparticle formulations leverage precise control of size, shape and composition, sterile filterability and scalable cGMP roll-to roll manufacturing to offering a low cost and simplified manufacturing advantage over traditional conjugate vaccines.
Advertisement