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2D FT-ICR MS/MS Analysis of lgG1

2D FT-ICR MS/MS Analysis of lgG1 content piece image

Recombinant monoclonal antibodies and derivatives are widely used as therapeutic drugs. Post-translational modifications during the manufacturing process and storage can result in product-related impurities. PTMs can change the efficacy, toxicity, or the clearance of the antibody; therefore they need to be well monitored.

Download this poster to learn how you can achieve 2D FT-ICR MS/MS analysis of IgG1 that includes:

  • Effective analysis of bottom-up mixtures.
  • Selectively analyzes phosphopeptides.
  • A new approach to top-down proteomics.
  • An alternative to MS/MS.