Automated Single Crystal Structure Determination - A Tool for Synthetic Chemists?
Poster Sep 13, 2010
Bernd Hinrichsen, Martin Adam, Michael Carr, Dieter Schollmeyer,
During recent years large improvements in software functionality and its ease-of-use have made single crystal X-ray structure determination easier than ever. These days most structures can be measured, processed, solved and refined using well selected defaults with no or little crystallographic knowledge. Recently, microfocus sources and CCD detectors both air-cooled, have entered the marketplace. Combining these innovations with an automated sample loader and an intelligent graphical user interface allows for the design of a table top single crystal diffractometer, which only requires a standard single phase power connection and no cooling water at all. An instrument taking advantage from these software and hardware developments would enable synthetic chemists or pharmacists to perform a complete single crystal structure analysis almost next to the reaction flask.
Measuring the 2nd Virial Coeffient and Molecular Density of Proteins to Improve CrystallizationPoster
The second virial coefficient of Human Serum Albumin (HSA) was measured using a SEC-MALS 20 detector connected to a Refractive Index concentration detector and an online differential viscometer. Two different buffer conditions, Phosphate buffer pH 7.4 and Citrate buffer pH 4.1 were used, which revealed interesting and contrasting dataREAD MORE
"In-vitro studies on hydroxamic acid- CT DNA binding"Poster
In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.READ MORE
Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume SpectrophotometerPoster
In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.READ MORE