Combining Imaging and OMICs: MALDI Guided SpatialOMx® Probes Proteomic Mass Profiles of Breast Cancer Tumor Subpopulations
Poster Apr 02, 2020
Janina Oetjen, Romano Hebeler, Frédéric Dewez, Corinna Henkel, Benjamin Balluff, Ron Heeren
While MALDI Imaging provides a direct link between tissue pathology and molecular expression, it lacks the in-depth molecular characterization attributed to 4D-OMICS strategies. SpatialOMx, an integration of MALDI Imaging with 4D-OMICs, yields a more comprehensive understanding of biochemical activity within the tissue microenvironment.
Download this poster to discover how the SpatialOMx workflow using timsTOF fleX provides detailed in-situ characterization of bioactivity across different tumor cell subpopulations by:
- Automated segmentation of tissue microenvironment based on label-free mapping of molecular expression
- Identification and location of distinctive tissue subtypes for laser microdissection and targeted OMICS analysis
- Performing in-depth 4D-proteomics analysis of excised material using PASEF