Determination of Nitrosamine Impurities in Losartan Potassium Drug Substance Using Triple Quadrupole LC-MS

The changing landscape for antibody-derived therapeutics, such as bi-specific monoclonal antibodies, Fab fragments and Fc-fusion proteins brings new purification challenges in the downstream processing of these molecules. Standard chromatography resins, such as Protein A, may not result in the most efficient purification process.

Download this poster to discover how ITC requires minimal assay development and sample preparation, allows early determination and elimination of false positives and can be used to identify fragments that will form a high-resolution co-crystal with the target protein.

Download this poster to discover how one-pot borylation/ Suzuki couplings to form sp2–sp2 C-C bonds achieves streamlined synthesis, in situ esterification using low-cost reagents and excellent functional group tolerance.