Employing Design of Experiments (DoE) to Evaluate the Robustness of an Automated Content Uniformity Method for the Triple Fixed Dose Combination Tablets
Poster Mar 03, 2014
Irena Maksimovic, Dongsheng Bu, David Lloyd
The content uniformity determination of three actives in Triple Fixed Dose Combination (FDC) tablets has been successfully automated using a TPW (Tablet Processing Workstation) bench-top robotic system. To our knowledge, this is the first TPW method developed for a triple fixed dose combo product. The method was implemented to enable in-process CU testing of drug product process justification batches, which represents a significant number of samples for this fast track project. The data will be used for process robustness evaluation and monitoring plan. During method development, a Design of Experiments (DoE) study with a center composite design was performed to optimize the operating ranges of the critical sample extraction parameters as to determine the interactions between these parameters. The parameters studies were diluent composition, homogenizer speed, time and number of pulses. The detail study design and results will be discussed in this presentation.
Using Elemental Analysis For Discrimination Of Pinot Noir Wines From Six Different Districts In An AvaPoster
The determination of geographical origin of wine is gaining increased interest by researchers and federal agencies around the world, partially due to increased fraud with regards to place of origin labelling. For wine, multi-elemental profiling of macro, micro, and trace elements has been proposed for determination of authenticity. Commercial wines from different wineries in 5 different neighborhoods within one AVA show characteristic elemental fingerprints. Macro, micro and trace elements as well as elemental ratios contribute to the observed separation, indicating the involvement of multiple factors and underlying mechanisms, including location and soil composition, elemental uptake by vine and rootstock, viticulture and nutrient management, water sources, and small differences in the different wineries.READ MORE
Fast arsenic speciation analysis of wines and rice with LC-ICP-QQQPoster
This method was designed in response to recent and proposed food standards, both international and national, that limit inorganic arsenic rather than total, organic, or individual arsenic species such as arsenite (AsIII) and arsenate (AsV). Analysis time is 10x faster than the current FDA regulatory method, increasing sample throughput, avoided spectral interferences and dramatically increased sensitivity. Validation data from two laboratories demonstrate the method’s accuracy and reproducibility of both wine and rice matrices in a single analytical batch.READ MORE
Overcoming the Challenges of Analysing Ionic Polar Pesticides in FoodPoster
Here, the novel application of the Waters’ Torus DEA column is presented, showing the improved performance of a UPLC-MS/MS method for the underivatised
analysis of glyphosate and a selection of other anionic pesticides.