MALDI Imaging Mass Spectrometry for the Study of Cardiovascular Pathology
Poster Mar 04, 2019
Takashi Nirasawa, Megumi Terada, Hiroko Namba, Nobuto Kakuda, Patrick Bruneval, Hatsue Ishibashi-Ueda and Masaya Ikegawa.
Cardiac Amyloidosis represents a growing number of diverse and devastating diseases which comprise cerebral forms such as Alzheimer's disease and cerebral amyloid angiopathy. These diseases are characterized by the aggregation of normally soluble, natural proteins or their fragments into highly ordered amyloid fibrils that deposit in target organs leading to dysfunction.
This poster highlights how a comprehensive MALDI mass spectrometry (MALDI-IMS) approach to formalin-fixed paraffin-embedded (FFPE) tissue samples was developed to study cardiovascular pathology.
Download this poster to learn: -
- How a MALDI-IMS protocol for FFPE samples of human cardiac biopsy was established
- How typing cardiac amyloidosis from FFPE samples can be achieved with MALDI-IMS
The changing landscape for antibody-derived therapeutics, such as bi-specific monoclonal antibodies, Fab fragments and Fc-fusion proteins brings new purification challenges in the downstream processing of these molecules. Standard chromatography resins, such as Protein A, may not result in the most efficient purification process.READ MORE
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