Stable Isotope Dilution Analysis of Organic Pollutants Using LC-MS/MS (QqQ) and Isotope Pattern Deconvolution
Poster Nov 25, 2010
A. Castillo, E. Gracia-Lor, A.F. Roig-Navarro, P. Rodriguez-Gonzalez, J.V. Sancho and J.I. García Alonso
For quantitative purposes the main limitation is the ion suppression caused by matrix components when using an electrospray ion source. The use of stable isotopically labelled compounds as internal standards (deuterated or 13C-labelled) is normally the preferred strategy to correct for such problem. To this end, a calibration graph is required using the natural and labelled intensity ratio of the more abundant ions.
Isotope Pattern Deconvolution (IPD) appears as a promising alternative to improve the determination of organic pollutants, since it allows spectral overlap between natural and labelled clusters as well as not requiring an isotope dilution calibration graph.
The poster highlights an Isotope Dilution AnaIysis methodology based on the Isotope Pattern Deconvolution approach, which has been applied for the first time to LC-ESI-MS/MS (QqQ) in SRM mode.
A New Tool for the Automated Sample Preparation of Whole Blood Samples by LC-MS using a Commercial AutosamplerPoster
Automated sample preparation reduces the costs per sample and minimizes sample handling errors. Usually expensive and highly specialized pipetting robots are used. However, most of these systems are not designed with a direct interface for LC-MS applications. In addition common pipetting systems are not optimized for smaller scale sample series. Here we present a new tool for liquid handling of whole blood samples and direct sample injection.
Multi-Residue Pesticide Analysis in Food Matrices Using Ultivo Triple Quad LC/MSPoster
Regulatory agencies have set maximum residue levels for hundreds of pesticides and their metabolites in foods.READ MORE
Analysis of Mycotoxins in Food Matrices using the Innovative Ultivo Triple Quad LC/MSPoster
A study demonstrating the accuracy and sensitive quantification of up to 12 regulated mycotoxin compounds in three commonly regulated foods.READ MORE
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