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Agilent Solutions for SFC with Mass Spectrometric Detection

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Agilent Technologies, Inc. has announced that all of its LC/MS instruments now include support software for control of supercritical fluid chromatography (SFC/MS).

This enhanced capability enables faster separation, orthogonal selectivity to liquid chromatography, and reduced need for organic solvents.

Used together, these hardware-software solutions for SFC/MS further streamline the high-volume analysis of complex samples, making them ideal for use in a variety of industries.

Pharmaceutical, food science, lipodomic, metabolomic, environmental and petrochemical laboratories can use SFC/MS to analyze a range of compounds (e.g., chiral, achiral, polar and nonpolar), including closely related compounds in complex matrices.

SFC is fully compatible with atmospheric pressure ionization mass spectrometry and hyphenation with MS detection increases peak resolving capacity, resulting in a greater SFC application range.

"The operation of SFC on Agilent's 6400 Series QQQ LC/MS and 6200/6500 TOF/Q-TOF previously required the use of two software platforms," said Lester Taylor, Agilent's director of LC/MS product marketing.

Taylor continued, "Agilent MassHunter software is now capable of controlling the Agilent 1260 Infinity Analytical SFC system. Use of a single software platform enables our customers to benefit from a fully integrated system for instrument control, data acquisition and analysis."

In addition to its analytical SFC system, Agilent is the only company offering a hybrid SFC/UHPLC system, which enables seamless switching between complementary modes in routine use and makes method development easier and faster. Both the SFC and the SFC/UHPLC system can be interfaced with Agilent LC/MS systems.

Now, reliable instrument control for method development and routine analysis is available with integrated software for SFC/MS. SFC/MS enables fast, high-resolution separation of compounds that cannot easily be separated by LC methods, with limited use of organic solvents.