We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS
Product News

Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS

Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS
Product News

Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS


Want a FREE PDF version of This Product News?

Complete the form below and we will email you a PDF version of "Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Thermo Fisher Scientific has developed a simple, fast, sensitive, and robust capillary ion chromatography (IC) analytical method to simultaneously quantify three bisphosphonate pharmaceuticals (etidronate, clodronate and tiludronate) and three commonly used excipients (benzoate, hydroxybenzoate and citrate).

Application Note 1001: Quantitative Determination of Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS uses a Thermo Scientific Dionex IonPac AS18-Fast capillary anion-exchange column to achieve chromatographic retention and resolution for target analytes.

The elimination of derivatization steps simplifies the workflow and improves method throughput.

Detection by suppressed conductivity provides sufficient sensitivity for quality control (QC) analysis and mass spectrometry (MS) offers additional selectivity and sensitivity for bisphosphonates in complex matrices, such as biological fluids.

Bisphosphonates are a group of compounds that are used as active pharmaceutical ingredients (APIs) to treat bone disorders and related conditions, including osteoporosis, Paget’s disease, and hypercalcemia.

This application note and many others can be found at www.thermoscientific.com/dionex under the Documents tab.

Advertisement