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Bruker Receives Order from the University of Utrecht for a Novel 527 GHz Solid State DNP-NMR System for Research on Membrane Proteins and Protein Complexes

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Based on Bruker's proven 263 GHz Solid State DNP-NMR system, this new development aims to double the field strength at which commercial DNP-NMR can be performed, in order to deliver the highest sensitivity in solid state NMR. The expected enhancements will open new frontiers in structural biology and membrane protein research.

The first system is expected to be delivered to the Bijvoet Center for Biomolecular Research at the University of Utrecht, setting the ground for a long-term research collaboration between of Professor Marc Baldus and Bruker. The aim is to develop high-field DNP techniques and applications for innovative biomolecular studies involving the structure, dynamics and function of membrane proteins and protein complexes. Funds for the purchase of the 527 GHz Solid State DNP-NMR system were provided by a competitive award from the Dutch Science Foundation (NWO) with matching funds from the University of Utrecht.

DNP can significantly enhance the sensitivity of many solid state NMR studies by transferring polarization from the electron spins to the nuclear spins. The solid state DNP-NMR technology commercialized by Bruker finds it origins in the pioneering work of Robert Griffin and Richard Temkin at the Massachusetts Institute of Technology. The 527 GHz Solid State DNP-NMR system will utilize a 527 GHz gyrotron as the high-power microwave source, an 18.8T (800 MHz NMR frequency) superconducting 89 mm widebore magnet, plus Bruker's ultra-fast Avance(TM) III electronics.

Dr. Marc Baldus, Professor of Structural Biology at the University of Utrecht, commented: "The new instrument will provide exciting possibilities to bridge the gap between traditional structural biology and cell biology. Using DNP-NMR, we will be able to obtain atomic information about biological processes and their failure under in-situ conditions."

Dr. Werner Maas, President of Bruker BioSpin, added: "We are excited by this opportunity to collaborate with Professor Baldus and to participate at the forefront of science. We are confident that our collaboration and the new 527 GHz DNP-NMR system will yield breakthrough capabilities and results, and will provide novel insights into the understanding of protein function and interactions."