External Announcement: Determination of Tartrate in Drug Products in Just 10 Minutes

Thermo Fisher Scientific has announced two new ion chromatography (IC) methods designed to reduce time and labor and increase accuracy when determining tartrate in drug products containing tolterodine tartrate.

Application Note 1002: Determination of Tartaric Acid in Tolterodine Tartrate Drug Products by IC with Suppressed Conductivity Detection demonstrates that these methods are accurate and reproducible, with analysis times as low as 10 minutes.

Both approaches use an electrolytic suppressor, which eliminates the time and effort to prepare dilute sulfuric acid regenerant.

The first method uses a Reagent-Free™ IC (RFIC™) system and therefore requires only the addition of deionized water for eluent and suppressor regenerant production.

This 10-minute method demonstrates improved accuracy and productivity because both eluent and regenerant are prepared automatically, eliminating the time and effort required to manually prepare these reagents while also reducing the possibility of errors and contamination.

The second method uses a carbonate/bicarbonate eluent and has an analysis time of 12 minutes.

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