External Announcement: Effective Determination of Dibasic Acids
Product News May 17, 2012
Thermo Fisher Scientific has announced an effective new method for the determination of succinic, glutaric, and adipic acids in solutions of mixed dibasic acids generated during cyclohexane oxidation.
Application Note 285: Determination of Succinic, Glutaric, and Adipic Acids as Quality Control of Cyclohexone Production demonstrates use of our liquid chromatography system (Thermo Scientific Dionex UltiMate™ 3000 RSLC system) with organic acid analytical column (Thermo Scientific Acclaim™ OA column) and mass spectrometry (MS) detection to achieve a fast baseline separation of these three dibasic acids with good resolution values (Rs ≥ 2.6), good method reproducibility, excellent linearity within 0.1 to 5 mg/L, and accurate results for industrial samples.
Cyclohexone is the key intermediate for the production of adipic acid, an important compound for the synthesis of nylon 66.
Cyclohexane oxidation is the normal method for the production of cyclohexone; and succinic, glutaric, and adipic acids, as well as their dehydration products, are the main by-products.
The three aliphatic dicarboxylic acids are also important chemical raw materials, and their determination is important for the quality control of cyclohexone production and recycling of the by-products.