We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience. You can read our Cookie Policy here.


Highly Sensitive and Precise In Vivo Luminescence Imaging

A lentivirus.
Listen with
Register for free to listen to this article
Thank you. Listen to this article using the player above.

Want to listen to this article for FREE?

Complete the form below to unlock access to ALL audio articles.

Read time: 1 minute

AMSBIO announce a new range of pre-made Nano-Lantern lentivirus products that utilize a proprietary lentiviral vector system to enable highly sensitive and precise in vivo luminescence imaging.

This cutting-edge Nano-Lantern lentivirus technology, which consists of an enhanced Renilla-Luciferase connected to an Orange Fluorescent protein (OFP), represents a significant improvement over previous methods and is poised to revolutionize many in vivo imaging applications.

Want more breaking news?

Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.

Subscribe for FREE

Fluorescent markers and bioluminescence are widely used techniques for in vivo imaging in living cells. While fluorescence imaging is an extremely useful tool, it requires external excitation from laser light. Common drawbacks of using laser light excitation include autofluorescence, phototoxicity, and photobleaching. By comparison, bioluminescence imaging does not require light activation but gives low brightness emissions and typically requires prolonged exposure times, making it difficult to observe small, rapidly moving structures.

The new lentivirus products, introduced by AMSBIO, are based upon a novel bioluminescence imaging method called Nano-Lantern which uses a bioluminescence resonance energy transfer (BRET) approach to significantly enhance signal intensity.

Beneficially, Nano-Lantern bioluminescence imaging also has an extremely low-level background signal, making it more sensitive and quantitative. When linked to a targeting protein, Nano-Lantern lentivirus products emit light in response to specific biological activity enabling dynamic real-time visualization in living organisms. Combining dynamic visualization with enhanced signal intensity and low background noise - Nano-Lantern lentivirus has been demonstrated to provide bright and high-resolution imaging of small, rapidly moving sub cellular structures.