We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Hybrid Drying Technique Generates Powder Samples from HPLC Fractions
Product News

Hybrid Drying Technique Generates Powder Samples from HPLC Fractions

Hybrid Drying Technique Generates Powder Samples from HPLC Fractions
Product News

Hybrid Drying Technique Generates Powder Samples from HPLC Fractions

Genevac LyoSpeed™

Want a FREE PDF version of This Product News?

Complete the form below and we will email you a PDF version of "Hybrid Drying Technique Generates Powder Samples from HPLC Fractions"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Driven by the requirement for completely dry samples, pharmaceutical compound handling groups are increasingly using SP Scientific’s Genevac LyoSpeed™, a hybrid process combining conventional centrifugal evaporation and lyophilization, as their preferred method for drying HPLC reverse-phase solvent fractions.

Using LyoSpeed™ technology on Genevac EZ-2 Elite and Series 3 HT evaporators, HPLC fractions can be automatically concentrated to a few milliliters, then frozen and rapidly lyophilized to produce a diffuse dry powder, which can easily be re-dissolved or weighed out.

Traditional concentration of reverse-phase HPLC fractions to dryness in a Genevac evaporator is a fast and safe process. However, for certain compounds a fully dried result can be hard to achieve due to compound interactions with water, resulting in formation of a gum or oil. Such samples, which are not completely dry, are of little use in biological assays since accurate weights cannot be obtained.

The application of LyoSpeed™ technology produces, with most samples, a dry powder rather than the traditional thin film, making downstream processing far easier since compounds can be more easily removed from the evaporation vessel. The resultant dry powder is not excessively fluffy as would be obtained from conventional freeze-drying. This avoids the problems associated with static formation, particularly when trying to weigh out such compounds, and also helps prevent the possibility of airborne contamination, especially important if the compound happens to be harmful or even toxic.
Advertisement