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IC Method for Determination of Voriconazole Related-Compound F
Thermo Fisher Scientific has announced an ion chromatography (IC) method that meets all the requirements of the proposed U.S. Pharmacopeia monograph method for determining voriconazole related compound F in voriconazole.
Application Note 1022: Determination of Voriconazole Related Compound F in Voriconazole Using IC demonstrates that this method is sensitive, repeatable, and accurate using the solvent-compatible anion-exchange column specified in the proposed monograph with chemically suppressed conductivity detection.
Determination can be made in 5 mg/mL sample solutions containing as low as 0.002% voriconazole related compound F.
Voriconazole is a second-generation triazole antifungal approved by the U.S. Food and Drug Administration in 2002 for the treatment of invasive aspergilliosis and other serious fungal infections.
Invasive aspergilliosis is a rapidly progressive and often fatal infection that occurs in severely immunosuppressed patients, recipients of bone marrow and organ transplants, and those undergoing chemotherapy.
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