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New Nano LC System with ProFlow Technology Offers Advanced Low-flow Performance

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Scientists performing nano liquid chromatography/mass spectrometry (LC-MS) analyses who seek accurate quantitation and analyte identification can now use a system designed to deliver higher retention time precision and ease of use. 

The latest version of the Thermo Scientific UltiMate 3000 RSLCnano UHPLC system combines higher nano LC performance with versatility and ease-of-use. New ProFlow technology increases retention time precision, resulting in high-quality data with accurate quantitation. Additionally, the system offers reduced start-up time and simplified system operation so that researchers can focus more time on data acquisition and analysis. 

“Life scientists are pushing research boundaries, but they also rely on nano flow technology to enable more productive and efficient workflows,” said Remco Swart, Ph.D., director, LC-MS technologies, Thermo Fisher. “Our new nano UHPLC system combines the precision of ProFlow technology with ease of operation so that researchers can focus less on the technology and more on their work.”

The UltiMate 3000 RSLCnano offers a wide flow range (nano-to-micro flow rates) in UHPLC mode as well as an additional micro-to-analytical flow ternary gradient pump for increased versatility. As a result, almost any low-flow workflow can benefit from this system. Dedicated kits are available for many standard and advanced (e.g. two-dimensional) workflows. All connections use Thermo Scientific nanoViper fingertight fittings to ensure rapid and easy set-up and virtually zero-dead-volume connectivity. Additionally, dedicated software is available to integrate the system with Thermo Scientific mass spectrometers.

“ProFlow technology allows long-term nano LC-MS operation with less maintenance and the highest performance,” said Mark Larance, Ph.D., University of Dundee in Scotland, after testing the new technology.

The UltiMate 3000 RSLCnano HPLC system will be exhibited in booth 10 at the 14th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology in Ghent, Belgium. The event takes place Jan. 27-29. Dr. Swart will introduce the new features of the system in a seminar entitled ”New Nano LC Performance Levels for Proteomics Workflows,” which takes place on Jan. 28 from 1:30-2:15 p.m.