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New Shimadzu MALDImini-1 Digital Ion Trap Mass Spectrometer Provides Fast, High-Sensitive Measurements through an Ultra-Compact Design

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Shimadzu Scientific Instruments (SSI) announces the release of the MALDImini™-1, the first commercially available compact MALDI digital ion trap mass spectrometer. The MALDImini-1 fits in a space the size of a piece of paper, while allowing fast high-sensitivity measurements and detailed structural and qualitative analyses over a wide mass range, even with sub-microliter sample volumes.

With its simple configuration, it is possible to install the compact MALDImini-1 in small places where mass spectrometers previously could not fit. Its unique Digital Ion Trap (DIT) technology, along with the innovative design of the laser optics, sample stage, and vacuum exhaust system, drastically reduces the space needed for the device. The small size and corresponding lower power requirements allow it to be plugged into a conventional AC power supply.

Users can place the MALDImini-1 on a workbench and check MS results right next to the sample preparation area, allowing for a more convenient workflow. Sample and matrix are simply spotted on the sample plate, dried, and loaded into the instrument. Analysis can begin in as little as five minutes. This fast, simple setup enables users to conduct and repeat even in-depth structural analyses in a short time span.

The system’s digital ion trap uses rectangular wave RF to allow ion trapping up to 70,000 Da. This capability, when combined with a MALDI source, enables high-sensitivity MSn analysis in a broad range of applications. In addition to checking the mass of smaller biomolecules, such as peptides and glycans, the unique features of the digital RF waveform allow analysis of higher molecular weight species up to 70,000 Da. Furthermore, the MS/MS and MS3 functionality of the DIT allows researchers to carry out comprehensive structural analyses, such as direct glycopeptide analysis, post translational modification analysis, and branched glycan structural analysis.

The MALDImini Console with dedicated control software lets users take measurements by setting simple analysis parameters. Switching between MS, MS/MS and MS3 modes is quick and easy for seamless analysis. Data can be exported in mzML or mzXML formats.

The device easily integrates with powerful processing tools to analyze data, such as MASCOT for identifying protein digests, SimGlycan™ for processing MSn data for glycans, and eMSTAT Solution™ for statistical analysis.