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Safeguarding HPLC System Operation

Solvent Line Monitor connected to an HPLC system, detecting gas microbubbles, with highlighted close-up of the sensor.
Credit: TESTA Analytical.
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The Solvent Line Monitor from TESTA Analytical is a valuable addition to any HPLC system designed to detect any problems caused by undissolved gas microbubbles and automatically close down the system.


The presence of undissolved gas microbubbles can result in changes in retention time, pulsating baseline, unexpected changes to peak area, irregular peak shape, pump outage and excessively high back pressure. As a result of these problems, accuracy and precision can decline to the point where scientists may be unable to distinguish between trace amounts of analytes and the system baseline.


Designed to monitor up to two HPLC pump feed lines simultaneously, the Solvent Line Monitor non-invasively checks the status of liquid flows and will give an alarm and stop operation if any gas bubbles are detected thereby safeguarding your HPLC system operation.


The compact and easy-to-use Solvent Line Monitor is programmable in terms of sensitivity, mode of operation and setting bubble detection alarms. The system set-up is a straightforward process using a highly intuitive PC-based app which is included with each Solvent Line Monitor. Gas microbubble detection parameters including the minimum size, frequency and number of bubbles can be configured using the PC app which also provides facility for different actions to be taken once an alarm status is detected, for example a simple beep or a stop signal.