Shimadzu Releases LabSolutions Insight Biologics, Software for Oligonucleotide Characterization
Complete the form below to unlock access to ALL audio articles.
Shimadzu Corporation announces the release of LabSolutions Insight Biologics, software for oligonucleotide characterization for use with the LCMS-9030 and LCMS-9050 high-performance liquid chromatograph quadrupole time-of-flight (Q-TOF) mass spectrometers. Insight Biologics automates the oligonucleotide characterization workflow and significantly improves efficiency. The software enables confirmation of products and identification of unknowns, and uses DDA-MS/MS to provide base-by-base sequence information, site specific modifications, and sequence mapping to assist in the important field of nucleic acid pharmaceuticals.
LabSolutions Insight Biologics was developed based on the results of collaborative research with PeptiStar Inc., a pharmaceuticals contract development and manufacturing organization (CDMO) for peptide pharmaceuticals*1 and nucleic acid pharmaceutical ingredients. In evaluating the characterization process, samples were used that mimicked the nucleic acid pharmaceuticals provided by PeptiStar, enabling precise characterization. This software was developed in accordance with the workflow needed, from research and development to the process of pharmaceutical ingredient manufacturing and impurity confirmations, making it a comprehensive yet user-friendly platform.
Want more breaking news?
Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your inbox every day.
Subscribe for FREEFeatures
Fast, Efficient Oligonucleotide Characterization
Impurity identification during the process of synthesizing oligonucleotides can take a great deal of time and effort. Shimadzu has developed a simple and rapid characterization workflow based on the results of collaborative research with PeptiStar. A comprehensive search for the principal components and their related impurities is performed automatically from their MS and MS/MS spectra*2, reducing the time needed for characterization by 90% over conventional workflows.
Easy Workflow for Technicians
Proprietary software functions offer a superior user experience for any operator. In this type of research, the nucleotide sequence for the principal components must be entered before the oligonucleotide sequence measurements, which is a complicated and error-prone step. With a function that depicts the nucleotide sequence information as a structural formula in real time, the principal components entered can be checked visually. In addition, the software is equipped with a function for switching the display between full mode, for checking the accuracy of the base sequence*3, and branch mode, for checking the positions where impurities tend to be produced, enabling a more accurate evaluation of the estimated sequence.
