We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Tosoh Bioscience Introduces TSKgel® FcR-IIIA-NPR Columns
Product News

Tosoh Bioscience Introduces TSKgel® FcR-IIIA-NPR Columns

Tosoh Bioscience Introduces TSKgel® FcR-IIIA-NPR Columns
Product News

Tosoh Bioscience Introduces TSKgel® FcR-IIIA-NPR Columns

TSKgel® FcR-IIIA-NPR Columns

Want a FREE PDF version of This Product News?

Complete the form below and we will email you a PDF version of "Tosoh Bioscience Introduces TSKgel® FcR-IIIA-NPR Columns"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Tosoh Bioscience LLC, a provider of chromatographic solutions for the separation of biomolecules, announced the introduction of its TSKgel FcR-IIIA-NPR HPLC column. This is the world’s first FcRγ affinity chromatography analysis column for antibody drugs and was developed independently by Tosoh Corporation.

Monoclonal antibodies (mAbs) comprise the largest class of glycosylated protein therapeutics currently on the market and glycosylation is known to be a major source of mAb heterogeneity. Glycosylation is a critical factor in drug product solubility, kinetics, stability, efficacy, and immunogenicity. The TSKgel FcR-IIIA-NPR column is a high performance affinity chromatography column for the analysis of IgG glycoforms. The stationary phase utilizes a recombinant human Fcγ receptor IIIa as a ligand bound to a nonporous polymethacrylate polymer. The resulting elution profile of the glycoprotein mimics antibody-dependent cellular cytotoxicity (ADCC) activity, which is correlated to the composition of the N-glycans.

A rapid thirty minute separation allows the analysis of large numbers of mAb samples to gain valuable initial information on the distribution of glycoforms and expected ADCC activity. This initial and efficient method can be applied to purified samples and supernatant alike and can therefore be used in many phases of development and production such as cell line screening in early R&D, biosimilar/originator comparison, upstream development and optimization, monitoring of glycoengineering, or lot-to-lot comparison in QC.

TSKgel FcR-IIIA-NPR columns are now available for sale in the Americas from Tosoh Bioscience LLC.
Advertisement