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Tosoh Bioscience Introduces TSKgel® UP-SW Aggregate UHPLC/HPLC Columns

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Tosoh Bioscience LLC, a provider of chromatographic solutions for the separation of biomolecules, has announced the introduction of TSKgel UP-SW Aggregate size exclusion chromatography (SEC) columns. These columns are the latest addition to the TSKgel UP-SW series and are now available for sale in the Americas from Tosoh Bioscience LLC.

Antibody therapeutics are enjoying high growth rates, the major areas of therapeutic application being cancer and immune/inflammation related disorders including arthritis and multiple sclerosis. Today, new antibody formats are entering clinical phases, with some of the new formats having a higher molecular weight than conventional antibodies. The biological phenomenon of protein aggregation is a major issue in therapeutic protein development, since the presence of these impurities reduces the potency of the drug formulation, even if non-toxic. Monoclonal antibodies must be free from these aggregate impurities.

Size exclusion chromatography is a widely applied technique for protein characterization and quality control. TSKgel UP-SW Aggregate SEC columns are 3 μm, 30 nm pore size analytical columns ideal for the separation of these higher molecular weight antibodies and monoclonal antibody (mAb) aggregates. Available in 4.6 mm ID × 15 and 30 cm lengths, TSKgel UP-SW Aggregate columns are compatible with both UHPLC and HPLC systems. These columns feature high pore volume per unit column volume, low sample adsorption (due to the derivatization of the particle surface with ligands containing diol functional groups) and excellent column efficiency, all contributing to unsurpassed sample resolution.