Tosoh Bioscience Launches Its Holistic Multi-Column Chromatography Solution for Downstream Process Intensification
Tosoh Bioscience GmbH, a provider of chromatographic solutions for the separation and purification of biomolecules, announced the launch of the Octave BIO Multi-Column Chromatography (MCC) system. This system, combined with the SkillPak BIO pre-packed columns, enables customers to quickly and efficiently develop pre-clinical processes. Octave BIO is the first in a series of MCC instruments targeting all stages of biomolecule manufacturing, from pre-clinical to clinical and GMP manufacturing. The company is expected to launch Octave PRO, a GMP manufacturing scale MCC instrument, by Q3 of 2023. The MCC line of instruments is part of the company’s initiative to improve biomanufacturing productivity and provide much-needed process flexibility while maintaining the highest product quality and reducing the overall cost of production.
Octave BIO Multi-Column Chromatography Systems
Specifically designed for the intensification of biomolecule purification processes, the Octave BIO is a comprehensive multi-column chromatography system for process development and proof of concept. The unique modular design can accommodate a wide range of requirements and unlocks the resin savings, buffer savings, and other tangible benefits that MCC can provide. Consistent with the typical bioprocess application of MCC, this versatile system can accommodate various processes, such as continuous AFC capturing, gradient polishing, and intensified batch chromatography.
The system flow path features PEEK tubing and a unique proprietary biocompatible valve block design that allows for the connection of 1 to 8 columns to accommodate increasingly intensified upstream titers while reducing the clutter of rotary valves and external tubing. The system also features six independently driven pumps each of which are user replaceable among four sizes to cover a wide range of process scales. Built-in UV, conductivity, and pH detectors enable complete process monitoring, while added features like the onboard sample injector, mixer, and gradient capability enable process design experiments. Included BIOController™ and ProComposer™ 21 CFR Part 11-compliant software tools provide an easy-to-use interface to understand and implement multi-column chromatography, in addition to the Method Wizard, which facilitates the conversion of conventional batch methods to MCC processes.
The Octave BIO is now available in EMEA from Tosoh Bioscience.