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Waters Introduces new Synapt G2 Mass Spectrometer
Product News

Waters Introduces new Synapt G2 Mass Spectrometer

Waters Introduces new Synapt G2 Mass Spectrometer
Product News

Waters Introduces new Synapt G2 Mass Spectrometer


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Waters Corporation has announced the introduction of a next-generation, high performance, mass spectrometer, the Waters® SYNAPT™ G2 System.

Taking qualitative and quantitative quadrupole time-of-flight mass spectrometry to new heights, the SYNAPT G2 system features new QuanTof™ and enhanced High Definition MS™ technologies intended to accelerate scientists toward their research goals.

The SYNAPT G2 System provides researchers with intuitive operation, application flexibility, and a totally new level of performance for biopharmaceutical, metabolite identification, metabonomics, proteomics, biomarker studies, and food and environmental applications. Waters introduced the SYNAPT G2 System at the 57th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics in Philadelphia, PA.

The SYNAPT G2 System is capable of outstanding qualitative and quantitative performance for both MS and the elevated data acquisition rates of SYNAPT G2 HDMS analysis.

For scientists this means performance in excess of 40,000 FWHM resolution, class-leading sensitivity, a data acquisition rate of 20 spectra/second, exact mass (1 ppm RMS) information and a dynamic range of up to five orders of magnitude. When paired with Waters ACQUITY® UltraPerformance LC® (UPLC®) technology, Waters SYNAPT G2 Mass Spectrometer makes maximum use of the power and speed of UPLC outclassing all other LC/MS and LC/MS/MS systems.

Waters is expecting to deliver the first SYNAPT G2 units during the fourth quarter of 2009.

The SYNAPT G2 System features new QuanTof technology that combines a high field pusher and dual stage reflectron with a novel ion detection system in an optimized, folded, TOF geometry. Together these features provide a new dimension of high resolution, exact mass and quantitative performance available at acquisition rates that are compatible with UPLC separations.

QuanTof’s high field pusher and dual-stage reflectron reduces ion turnaround times associated with pre-push kinetic energy spread while its dual-stage reflectron improves focusing of high energy ions. As a result QuanTof technology provides the highest levels of comprehensive TOF performance available.

SYNAPT G2's novel ion detection system combines an ultra-fast electron multiplier with hybrid ADC detector electronics to provide outstanding qualitative and quantitative performance for both MS for the elevated data acquisition rates of HDMS analysis.

Integrated second-generation Triwave™ Technology, the ion mobility resolving power of the Synapt G2, is up to four times higher than the original SYNAPT system. This means scientists can separate similar sample components – based on size, charge, mass, and shape - better than ever before and identify sample components that might have remained invisible to them until now.

With new DriftScope™ Mobility Environment Software (v2.1), the Synapt G2 comprehensively detects components, reveals new or subtle features in the data, and provides more efficient data processing workflows such as the measurement of a compound’s collisional cross section (shape). With this capability scientists can make new discoveries while significantly reducing the time required to deliver business and research-critical information.

The SYNAPT G2 incorporates the design philosophy of Engineered Simplicity™ that is a hallmark of Waters benchtop Xevo mass spectrometers and the first time Waters has introduced the design components into a versatile high-end research-grade mass spectrometry platform.

These features - including IntelliStart™ technology which calibrates and prepares the instrument for operation while continually monitoring its performance - automate set-up procedures, minimize the opportunity for human error, and make the mass spectrometer more “accessible” to those who may be new to mass spectrometry yet who need to generate high-quality results consistently.
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