Waters’ New Xevo G2-XS QTof Mass Spectrometer, Bringing Uncompromised Sensitivity and Exceptional Quantitative Ability to MS

Waters Corporation today introduced the Waters® Xevo® G2-XS mass spectrometer, a new high performance benchtop quadrupole time-of-flight (QTof) mass spectrometer, at the 62nd conference of the American Society of Mass Spectrometry (ASMS). Featuring the new XS Collision Cell, the Xevo G2-XS QTof stands alone among its peers in offering uncompromised analytical sensitivity and selectivity in a benchtop QTof mass spectrometer. Shipment of Xevo G2-XS QTof to customer laboratories is expected to begin at the end of the second quarter with MassLynx ® software and in the fourth quarter under the UNIFI® Scientific Information System.

“The technology embodied in the Xevo G2-XS benefits laboratory analysis in a number of ways. Most importantly, laboratories now have a dependable option for performing qualitative and quantitative experiments for both known and unknown analytes with a benchtop QTof instrument,” said Brian Smith, Vice President – Mass Spectrometry Operations, Waters Division.

The Xevo G2-XS QTof mass spectrometer combines the new XS Collision Cell with the proven, signature technologies of Tof-MRM, StepWaveTM and QuanTofTM to deliver optimum levels of robust sensitivity and selectivity, resulting in the detection of more low-level compounds than ever before.

For targeted quantitative experiments, Tof-MRM mode delivers a 10-fold improvement in signal-to-noise when compared to full scan mode, resulting in limits of detection and quantification that completely redefine expectations for a benchtop high resolution mass spectrometer.

Another feature of the Xevo G2-XS QTof is the Waters MSE technology, a patented method of data acquisition that comprehensively catalogs complex samples in a single analysis. One who uses it routinely for metabolite profiling is Jessica Prenni, Ph.D., a Waters Centers of Innovation Program honoree and Director of the Proteomics and Metabolomics Facility at Colorado State University. “My team and I agree MSE  technology is invaluable for non-targeted metabolite profiling. We’ve developed a new data analysis workflow that allows us to de-convolute the MSE data and recreate spectra for the metabolites that we’re seeing at both low-collision energy and high-collision energy. These spectra are then used to facilitate metabolite annotation. The ability to acquire MSE is really something that sets the Waters instruments apart,” says Dr. Prenni.