D614G : SARS-CoV-2 S1 Variant
Featured Product Jul 01, 2020
A recent study from Los Alamos National Laboratory has identified a major mutation on SARS-CoV-2 Spike. This D614G mutation has rapidly become dominant in these regions, suggesting this mutation may make the SARS-CoV-2 virus more transmissive. It's critical to understand the biology of this variant, particularly in the context of vaccine and drug design.
Sino Biological has developed a recombinant S1 protein with a D614G mutation (40591-V08H3). The recombinant 614G variant demonstrated an ACE2 binding activity.
In addition to the D614G mutation, several other mutations are also identified. Some of them are believed to enhance S1's ability to bind with ACE2. Sino Biological has developed a panel of mutated RBD proteins to facilitate the study of these variants.
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