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Intabio ZT System: icIEF Separation, UV Detection and MS Identification of Charge Variants on a Single Platform Integrated With the ZenoTOF 7600 System.
Early understanding of attributes that impact protein therapeutic stability is important to reduce risk and compress drug development timelines. One such critical attribute that requires monitoring during cell-line and process development for a given biologic drug candidate is its charge profile.
The process of identifying individual charge variant components is time and labor intensive. Interpreting their structural differences can take weeks and requires the use of multiple analytical methods and instruments, increasing the complexity of the charge heterogeneity analysis assay, and creating a bottleneck in gaining critical information for processes and team members downstream in the development pipeline.
With icIEF-UV/MS via the Intabio ZT system coupled with the ZenoTOF 7600 system you can separate, quantify and identify biopharmaceutical charge variants and their proteoforms in minutes on a single platform.
