CRISPR and Genome Editing – News and Features

Researchers explored the role of the TLE6 protein in male fertility using a novel mouse model. TLE6 deficiency caused significant reductions in sperm count and motility and led to abnormal sperm morphology.

A new type of off-the-shelf cell-based immunotherapy shows promise for B-cell lymphomas, and could make make future cellular immunotherapies less expensive and more accessible.

Technology Networks spoke with Dr. Thomas Dennison, University of Cambridge, to learn more about the advantages of using patient-derived organoids for modeling inflammatory bowel disease (IBD).

Researchers have developed a new strategy to enhance pharmaceutical production in Chinese hamster ovary (CHO) cells, which are commonly used to manufacture protein-based drugs for treating cancer, autoimmune diseases and much more.

A collaborative team has developed a new method to program molecular self-assembly predictably. Researchers created versatile materials like "Malteser molecules," which could serve as highly specific sensors or drug delivery agents.

A study reveals that the way cancer cells die after radiotherapy depends on DNA repair methods. By blocking specific repair pathways, scientists can prompt immune responses against cancer cells.

A study explores the molecular dynamics of CD28.ζ-CAR and 4-1BB.ζ-CAR T cells at the immune synapse, where CAR T cells bind to cancer cells. CD28.ζ-CAR T cells act like sprinters, killing cancer cells quickly but briefly

A study uncovers how H2O2-induced redox modification regulates the RNA demethylase SlALKBH2. This modification stabilizes SlALKBH2 and accelerates tomato ripening without altering its m6A demethylase activity.

Scientists at the University of Florida are testing a new type of citrus tree that can fight off the tiny insects responsible for citrus greening.

The adaptive immune system is highly complex and specific. In this article we focus on T cells, and discuss their development, their different functions, and what happens when they don't function correctly.