Electrophysiology – News and Features

Researchers have conducted a preclinical study on the effects of the drug empagliflozin, alone or in combination with sacubitril/valsartan, in the early phase following a myocardial infarction.

Two new research papers have mapped out which pathways in the brain are responsible for driving hunger, food seeking and satiety. The findings could help to refine weight-loss drugs and reduce their side effects.

Scientists have identified the discrete group of co-activated neurons in the brain that work to suppress binge drinking behaviors. This could become a new therapeutic target for alcohol dependency.

Researchers have discovered that the glycoprotein reelin is a marker for cocaine-activated neurons in the nucleus accumbens. Reelin plays a key role in cocaine-related gene expression, neuron excitability and behavior changes.

Researchers at Université de Montréal studied caffeine’s effect on sleep, revealing that it enhances brain signal complexity and criticality. These changes improve brain activity but may reduce restorative sleep, especially in younger adults.

A study from the Institute for Basic Science discovered the role of mini-exon B in brain connectivity and function. This microexon, part of the PTPδ gene, influences synapse formation and behavior.

Researchers have discovered microscopic structural changes in the aging heart that may help stabilize heart rhythm and protect against arrhythmia.

Research reveals that ketamine stabilizes brain activity in a dose-dependent way. The study used high-density EEG to track changes in brain stability, suggesting ketamine’s effects on brain dynamics might be central to its therapeutic use.

Thiamine derivatives, especially TTFD, have long been used to support energy, with recent studies suggesting they may enhance brain function. In rats, TTFD administration increased dopamine levels in the medial prefrontal cortex.

Researchers have visualized in real-time how ATP levels change in neurons during spreading depolarizations, which occur after a stroke.