Next-Generation Sequencing – News and Features

Researchers mapped HIV-1’s translation strategy, revealing RNA elements like uORFs, iORFs and an intricate frameshift site structure that regulate viral protein synthesis. These findings highlight ribosome pausing as a key mechanism.

Garvan Institute researchers discovered how chronic hepatitis C virus (HCV) infections lead to autoimmune diseases like cryoglobulinemic vasculitis. By identifying rogue B cell clones caused by persistent antibody clustering and mutations.

A study involving Black and Hispanic women identified two BV subtypes, with one significantly raising chlamydia risk. Advanced microbiome analysis linked specific bacterial imbalances to subsequent chlamydia infections.

A study reveals how Salmonella enterica leverages a small RNA, ManS, to regulate Neu5Ac metabolism and adapt to the host intestine. ManS originates from the 3′ UTR of mRNA via noncanonical RNase III cleavage.

A new study has lifted the lid on five species of root-lesion nematodes living in maize crops across New Zealand and suggested the existence of a hitherto-unsuspected cryptic species.

A landmark study analyzing data from over five million individuals across 29 countries uncovered 700 genetic variants linked to depression, with 100 identified exclusively due to diverse ethnic inclusion.

A study identified the mutation mechanism LTA chromothripsis in 50% of high-grade osteosarcoma cases, explaining its genomic instability and aggressive nature. The findings highlight loss of heterozygosity as a prognostic biomarker.

Whole-genome sequencing of endangered cockatoo species brings new insights into their genetics, potentially offering fresh hope for their survival.

UK Biobank's proteomics study will measure 5,400 proteins in 600,000 samples, tracking changes over mid-to-late life. By combining genetic, imaging and proteomic data, this initiative promises breakthroughs in disease diagnosis and drug discovery.

A USC-led study uncovers the evolutionary origins of mammalian outer ears, linking them to the elastic cartilage of ancient fish gills. Using genetic enhancers, researchers demonstrated a developmental connection across species.