RNA-Seq – News and Features

Researchers have uncovered surprising ways transcription factors – the genetic switches for genes – regulate plant development, revealing how subtle changes in a lipid-binding region can dramatically affect growth.

An international study links GSK3B gene variants to autism and developmental delays. By analyzing 15 cases and using mouse models, researchers showed disrupted development in excitatory neurons.

New research suggests severe COVID-19 arises in part from the SARS-CoV-2 virus’s impact on mitochondria, which can help trigger a cascade of organ- and immune-system-damaging events.

A study uncovers that CD8+ T cells in ME/CFS patients exhibit exhaustion-like states, a condition linked to chronic immune activation. This discovery raises the possibility of adapting cancer immunotherapies to reverse T cell exhaustion in ME/CFS.

As muscles age, their cells lose the ability to regenerate and heal after injury. Researchers have created the most comprehensive picture yet of this process.

Researchers discovered that starlet sea anemones reshape their entire bodies during regeneration to maintain their original proportions. Using spatial transcriptomics, the team identified enzymes active throughout the body that realign tissues.

University of Copenhagen researchers uncovered how juvenile hormone regulates caste differentiation in pharaoh ants. By treating worker larvae with the hormone, researchers induced queen-like traits.

Standardized tissue handling is crucial in cancer research, ensuring the preservation of sample integrity and data quality. This enables comprehensive analysis and enhances understanding of cancer biology, aiding therapeutic discoveries.

Researchers mapped gene expression across the mouse intestine, revealing its stability and adaptability to changes like inflammation. The study identified immune-controlled regions and resilient spatial patterns.

Researchers have used whole-genome CRISPR interference screening to identify the “Achilles Heel” of drug-resistant tuberculosis and identify drugs that target these weaknesses to rapidly kill drug-resistant strains.