Screening Strategies in Drug Discovery – News and Features

News
Researchers Identify Previously Uncharacterized Gene Involved in DNA Repair
Researchers have identified several uncharacterized chromatin factors and a gene that are involved in DNA repair.

News
Death-Defying Molecule Could Slow Neurodegenerative Disease Progression
Researchers have identified a small molecule that can selectively block cell death. The findings lay the groundwork for next-generation neuroprotective drugs for degenerative conditions, which currently have no cure or treatments.

Article
Phenotypic Screening: A Powerful Tool for Drug Discovery
Phenotypic screening has re-emerged as a powerful strategy for identifying drugs based on their observable effects. Discover how phenotypic screening accelerates drug discovery, supports drug repurposing and enables novel therapeutic breakthroughs.

News
Researchers Design Scaffolds To Inhibit Drug Breakdown
Scientists have designed new drug frameworks that selectively target CYP3A4, one of the most critical CYP proteins. Structural insights from this work offer a roadmap for future drug developers to better evaluate drug interactions.

Article
High-Throughput Screening Techniques To Improve Cellular Drug Discovery
Drug discovery efforts have expanded beyond the traditional approaches of small molecules and antibodies to include cells. This article explores the use of microfluidic methods for high-throughput screening of cell-based drug products.

Industry Insight
Enhancing Drug Screening With Human-Relevant Models
In this interview, Sebastiaan J. Trietsch, Chief Technology Officer at MIMETAS, discusses how microphysiological systems are advancing drug discovery through scalable human-relevant models and AI integration.

News
Brain Energy Sensors Control Sleep-Wake Cycles
Researchers discovered that ATP-sensitive potassium (KATP) channels in the brain play a pivotal role in sleep regulation. These energy sensors help maintain sleep-wake cycles and smooth transitions between them.

Article
Optimizing Cell Culture Models To Mimic the Tumor Microenvironment
The complexity of the TME in vivo limits the conclusions that can be drawn from in vivo models. Optimizing cell culture models to mimic the TME is vital to understanding cancer progression and the development of optimized therapies.

News
Glucose Revealed To Be a Master Regulator of Tissue Differentiation
New research shows that glucose regulates tissue differentiation by binding to hundreds of proteins throughout the cell to modulate their function and promote differentiation.

Industry Insight
AI Is Redefining the Role of the Scientist – Here’s How
The integration of AI and automation is transforming laboratory research, improving overall efficiency and scalability. However, scientists must be cautious as over-reliance on AI may weaken critical thinking and troubleshooting skills.
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