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Screening Strategies in Drug Discovery – News and Features

DNA coils and breaks, illustrating DNA damage.
News

Researchers Identify Previously Uncharacterized Gene Involved in DNA Repair

Researchers have identified several uncharacterized chromatin factors and a gene that are involved in DNA repair.
The 3D structure of the protein BAX, which is involved in cell death.
News

Death-Defying Molecule Could Slow Neurodegenerative Disease Progression

Researchers have identified a small molecule that can selectively block cell death. The findings lay the groundwork for next-generation neuroprotective drugs for degenerative conditions, which currently have no cure or treatments.
A scientist holding a 96-well plate on a lab bench, commonly used in phenotypic screening of drug compounds.
Article

Phenotypic Screening: A Powerful Tool for Drug Discovery

Phenotypic screening has re-emerged as a powerful strategy for identifying drugs based on their observable effects. Discover how phenotypic screening accelerates drug discovery, supports drug repurposing and enables novel therapeutic breakthroughs.
A molecule appearing from the inside of a drug pill.
News

Researchers Design Scaffolds To Inhibit Drug Breakdown

Scientists have designed new drug frameworks that selectively target CYP3A4, one of the most critical CYP proteins. Structural insights from this work offer a roadmap for future drug developers to better evaluate drug interactions.
High-throughput screening process in a laboratory, featuring a pipette dispensing liquid into a petri dish among automated testing equipment.
Article

High-Throughput Screening Techniques To Improve Cellular Drug Discovery

Drug discovery efforts have expanded beyond the traditional approaches of small molecules and antibodies to include cells. This article explores the use of microfluidic methods for high-throughput screening of cell-based drug products.
Digital wireframe of a human figure symbolizing data-driven human-relevant models in science.
Industry Insight

Enhancing Drug Screening With Human-Relevant Models

In this interview, Sebastiaan J. Trietsch, Chief Technology Officer at MIMETAS, discusses how microphysiological systems are advancing drug discovery through scalable human-relevant models and AI integration.
Woman sleeping peacefully with an eye mask, representing healthy sleep cycles and nighttime rest.
News

Brain Energy Sensors Control Sleep-Wake Cycles

Researchers discovered that ATP-sensitive potassium (KATP) channels in the brain play a pivotal role in sleep regulation. These energy sensors help maintain sleep-wake cycles and smooth transitions between them.
Scientist performing a cell culture experiment.
Article

Optimizing Cell Culture Models To Mimic the Tumor Microenvironment

The complexity of the TME in vivo limits the conclusions that can be drawn from in vivo models. Optimizing cell culture models to mimic the TME is vital to understanding cancer progression and the development of optimized therapies.
Stem cells with orange nuclei on a green background.
News

Glucose Revealed To Be a Master Regulator of Tissue Differentiation

New research shows that glucose regulates tissue differentiation by binding to hundreds of proteins throughout the cell to modulate their function and promote differentiation.
A glowing AI symbol surrounded by futuristic digital icons representing artificial intelligence, data security, cloud computing, and automation, hovering over an open human hand.
Industry Insight

AI Is Redefining the Role of the Scientist – Here’s How

The integration of AI and automation is transforming laboratory research, improving overall efficiency and scalability. However, scientists must be cautious as over-reliance on AI may weaken critical thinking and troubleshooting skills.
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