Spatial Biology – News and Features

The Discovery Spark program aims to help upcoming biotechnology and healthcare companies grow. In this article, we take a closer look at some of the innovative technologies of this year's Discovery Spark cohort.

University of California, Riverside scientists have designed novel agents that bind to and degrade Pin1, a protein linked to pancreatic cancer. These “molecular crowbars” destabilize Pin1, making it vulnerable to degradation.

Researchers at the University of Cincinnati found that copper accumulation fuels renal cell carcinoma by enhancing energy production in tumors. Elevated copper levels activate protective mechanisms that support cancer cell survival.

A study reveals that triple-negative breast cancer cells prompt immune cells to form "molecular bridges," leading to immune suppression. An antibody treatment blocking these bridges shows promise in enhancing the immune response.

An international team has developed a new imaging method that analyzes cancer cells and their surrounding tissue at a single-cell level. This innovative approach identifies distinct patient groups based on prognosis.

A study introduces a 3D-printed tumor model, named 3MIC, to simulate the conditions that lead to cancer cell metastasis. Researchers observed how tumor cells acquire migratory properties.

Researchers at Weill Cornell Medicine identified a mechanism by which ovarian tumors inhibit T cell lipid uptake, impairing immune response. By modifying the Transgelin 2 gene in CAR T cells, they enhanced their effectiveness against ovarian tumors.

Scientists have engineered CAR-T cells with on/off switches activated by existing drugs, enhancing safety in cancer therapy. This innovative approach allows for controlled responses to tumor antigens.

At this year’s HUPO annual meeting, the 24th version of the Human Protein Atlas has launched. We interviewed the HPA's program director, Professor Mathias Uhlén, to learn about its new features.

Alzheimer’s disease (AD) progresses in two phases, highlighting early inflammatory changes and the loss of specific inhibitory neurons. Researchers created a cellular timeline, offering potential new targets for therapy.