Structural Biology – News and Features

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Machine Learning Predicts Protein Behavior, Aiding Drug Design
Researchers developed ProtGPS, an AI tool that predicts protein localization in cells and how mutations affect disease. The model identifies functional disruptions and designs novel proteins for targeted therapies.

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Organoids, Beyond the Hype
The HUMANOID Center at UC San Diego is pioneering organoid research aimed at improving the reliability and reproducibility of these models, ultimately increasing drug testing accuracy and revolutionizing biomedical science.

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How Sudan Virus Infects Human Cells With Greater Efficiency Than Ebola
A new study finds that the Sudan virus, a deadly Ebola relative, binds to human NPC1 receptors with nine times greater affinity than Ebola. Using cryo-electron microscopy, researchers mapped its infection mechanism.

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How the Dengue Virus Hijacks Plasmin for Infection
Researchers have uncovered how the dengue virus uses its envelope protein to hijack human plasmin to enhance transmission.

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Understanding Endosomal Recycling Could Lead to New Disease Therapies
Researchers at UT Southwestern identified how SNX17 and Retriever interact to regulate endosomal recycling, a crucial process for protein transport. Using cryo-EM imaging, they revealed a key binding mechanism.

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How an Effective Cancer Therapy Was Redesigned To Make It Safer
UIC researchers have redesigned asparaginase, a key leukemia treatment, to reduce severe side effects like liver damage and blood clots. The modified enzyme is more effective and may treat other cancers like melanoma.

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Surveillance Model Detects Fast-Spreading SARS-CoV-2 Variants of Concern
Researchers developed a model that detects SARS-CoV-2 mutations linked to increased transmission, identifying high-risk variants before widespread outbreaks. The study highlights mutations in the spike protein and other viral regions.

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Numbering System Enables Efficient Comparison of Protein Domains
Researchers have developed a standardized numbering system for adhesion GPCRs, improving knowledge transfer and disease analysis. This AI-driven system, based on 14,000 modelled structures, facilitates comparative studies across species.

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How Is AI Shaping Proteomics and Multiomics?
Associate Professor Qing Zhong shared insights on AI breakthroughs in proteomics and multiomics, challenges in data sharing and his vision for a high-resolution lens on biology that could redefine science and healthcare.

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Some Proteins Find Their Match at Birth
The formation of protein complexes is a delicate process, with some proteins finding their match at synthesis.
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