Drug Impurities? Is Your HPLC Method up to Standard?
This Teach Me in 10 episode features our guest, Chris Tuczemskyi, Product Marketing Manager at ThermoFisher Scientific. With a background in biochemistry and extensive experience in water testing laboratories, Chris offers valuable insights from his journey at ThermoFisher Scientific, where he has supported customers with chromatography solutions since 2014.
In this video, Chris explores the critical importance of impurity analysis in pharmaceuticals, addressing the challenges faced by analytical scientists in ensuring drug purity and patient safety. He explains how selecting the right detection strategies can overcome common hurdles like quantifying unknown impurities, managing gradient compatibility and achieving uniform response across analytes.
Watch this episode to understand:
- The significance of drug purity in pharmaceutical development and patient safety
- Practical approaches to analyzing samples with strong and weak chromophores
- How charged aerosol detection (CAD) can maximize accuracy when quantifying both APIs and impurities in a single run
Further Resources
How to develop better drug impurity analysis methods - Impurities can affect the safety and efficacy of medicines and biologic drugs, resulting in the potential recall of marketed drugs. This list provides top method development considerations to help you get started.
HPLC-CAD Learning Center - Discover the benefits of Charged Aerosol Detection for your HPLC analysis, plus expert tips on method development and optimization.
