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High Throughput Paper-Spray Mass Spectrometry for Validated Clozapine TDM

Therapeutic drug monitoring (TDM) represents significant workflow demands and revenue generation for clinical laboratories. A high throughput, validated paper spray mass spectrometry assay using the Thermo Scientific™ VeriSpray™ source is presented as a facile and rapid TDM strategy for the direct, quantitative analysis of clozapine and its metabolite in human serum samples. Quantitative results obtained compare favourably with a validated clinical LC-MS assay.

For Research Use Only. Not for use in diagnostic procedures. Thermo Scientific™ Orbitrap™ mass spectrometers are intended for General Laboratory Use Only, and not for Diagnostic or Clinical Use.

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