Genomic tools for Psilocybe cubensis propagation
Kevin McKernan, CSO at Medicinal Genomics will be joining us to discuss genetic variation in the Psilocybe cubensis synthesis pathway and the design of qPCR assays for simultaneous quantification of E. coli and Salmonella species contamination concurrent with Psilocybe cubensis species identification.
Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models
An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.
Effective Nuclei Isolation From Tissue for Single-Nucleus Sequencing
In this webinar, we present a standardized workflow solution, including easy and automated nuclei extraction and isolation for reproducible single-nucleus sequencing analysis.
Discovering Reprogrammed Molecular Pathways in Cancer Metastasis With MALDI Imaging
This presentation will highlight our recent progress in the discovery of N-glycans and phospholipids that significantly contribute to aberrant cancer metabolic pathways in primary tumors and metastases. We have also developed novel MALDI imaging approaches of drugs and drug metabolites that exploit key metabolic differences in tumors.
Innovations in Disease Modeling 2022
This inaugural online symposium will explore the tools and techniques being used to study diseases in the lab. Focus will be given to cell culture, organ-on-a-chip and organoid models, as well as, how innovations are enabling researchers to elucidate the underlying biological mechanisms of disease and support diagnostic and therapeutic development.
Reduce Cost of Matrix-Rich HPLC Separations
How To Increase the Cost Effectiveness for HPLC Separations of Challenging and Matrix-Rich Samples