Latest Whitepapers
Whitepaper
Studying nanoparticle-based drug delivery and targeting with Nanoparticle Tracking Analysis
This white paper addresses some of the latest work reported in the literature in which Nanoparticle Tracking Analysis (NTA) has been proposed, used and assessed in the study of nanoparticle-based drug delivery and targeting.
Whitepaper
Accelerating the deformulation workflow for oral solid dosage forms
In this white paper we introduce a workflow for OSD product deformulation and demonstrate how component specific particle size and shape data, obtained using Morphologically Directed Raman Spectroscopy (MDRS), can aid the preparation of a successful ANDA submission.
Whitepaper
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 3. DLS Deconvolution Algorithms
The basic types of DLS deconvolution algorithms used to extract the intensity weighted particle size distribution from the measured correlogram.
Whitepaper
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 2. Concentration Effects and Particle Interactions
The influence of concentration effects and particle interactions on DLS results, with a roadmap for identifying and distinguishing each type of concentration effect.
Whitepaper
Application of Dynamic Light Scattering (DLS) to Protein Therapeutic Formulations: Principles, Measurements and Analysis - 1. Basic Principles
An overview of the key principles of Dynamic Light Scattering: theory, correlation statistics, deconvolution algorithms, and the intensity to mass transform.
Whitepaper
10 Reasons that the Zetasizer Nano is Chosen for Scientific Success
The Malvern Zetasizer Nano is found in such a broad range of applied and research projects across all industries, because it is has the best specifications, the widest range of capabilities and continues to evolve to meet new requirements.
Whitepaper
Towards a unified biophysical characterization platform: Combining dynamic light scattering and Raman spectroscopy to determine protein structure and stability
The combination of dynamic light scattering (DLS) with Raman spectroscopy has the capability to characterize a wealth of chemical, structural, and physical parameters of therapeutic proteins.
Whitepaper
Improved understanding of the thermal stability of a monoclonal antibody and its modified version by use of DLS/Raman spectroscopy
The combination of Dynamic Light Scattering (DLS) with Raman Spectroscopy provides the capability to investigate a wealth of chemical, structural, and physical parameters about biotherapeutic proteins under formulation conditions.
Whitepaper
Use of DLS/Raman to study the thermal unfolding process of lysozyme
The combination of dynamic light scattering (DLS) and Raman spectroscopy has the ability to extract a wealth of chemical, structural, and physical parameters from aqueous protein suspensions.
Whitepaper
Sensitivity of a combined DLS/Raman technique to estimate the conformational and colloidal stability of protein therapeutics
Combining dynamic light scattering (DLS) and Raman spectroscopy provides the ability to extract a wealth of chemical, structural, and physical parameters from proteins at both low and formulation concentrations. DLS, used to study protein size, and Raman, used to determine protein conformation, is combined into a single instrument to monitor stressed protein samples under identical conditions.
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